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KMID : 1007520150240041467
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Food Science and Biotechnology
2015 Volume.24 No. 4 p.1467 ~ p.1474
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Honokiol, Magnolol, and a Combination of Both Compounds Improve Glucose Metabolism in High-fat Diet-induced Obese Mice
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Lee Young-Sil
Choi Sun-Sil
Takayuki Yonezawa
Toshiaki Teruya
Woo Je-Tae
Kim Hyo-Jung
Cha Byung-Yoon
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Abstract
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Honokiol and magnolol are neolignans contained in the Chinese medicinal herb Magnolia officinalis that exert anti-tumor and anti-inflammatory effects. Both compounds have been reported to enhance glucose uptake. Little is known about effects when used in combination. The effects of honokiol, magnolol, and a combination of both compounds on lipid and glucose metabolism in highfat diet-induced obese mice were investigated, and underlying mechanisms were examined. All 3 treatments significantly (p<0.05) reduced plasma total cholesterol and glucose levels, and improved glucose tolerance, compared with controls. In addition, treatments increased mRNA expression of the peroxisome proliferator-activated receptor (PPAR)-γ, glucose transporter (GLUT)-4, and adiponectin genes in white adipose tissue (WAT). Both compounds individually and in combination significantly (p<0.05) increased Akt phosphorylation and GLUT4 protein expression in WAT compared to the control group. Honokiol and magnolol improve dyslipidemia and hyperglycemia and act synergistically when used in combination.
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KEYWORD
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honokiol, magnolol, combination, high-fat
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